"In the Blood" is a song written and recorded by American singer-songwriter John Mayer. The song was released on May 1 as the third single from Mayer's seventh studio album The Search for Everything, following "Love on the Weekend" and "Still Feel Like Your Man". It's Mayer's first song officially released to country radio.
The song mentions Mayer's family influence. In his interview with NPR, Mayer said, "It's turning around and pointing at yourself and going 'What's in there?' It's a certain time in your life where you just want to turn yourself upside down and shake everything out and go.